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-Structure paper
| タイトル | Evolution of a core ribosomal innovation in octopus. |
|---|---|
| ジャーナル・号・ページ | bioRxiv, Year 2026 |
| 掲載日 | 2026年6月26日 |
著者 | Rishav Mitra / Richard Han / Trey J Scott / Anik G Grearson / Jessica A Willi / Christina G Liu / Hyeongju Kim / Michael C Jewett / Nicholas W Bellono / Amy Sy Lee / ![]() |
| PubMed 要旨 | Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and ...Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and sophisticated behaviors that rival vertebrates, but via an entirely divergent evolutionary history. Here, we serendipitously discovered that octopus ribosomes contain a structural break in the core ribosomal RNA that is unique among all animals. This break site enhances translation fidelity to reduce miscoding and subsequent protein aggregation, even when engineered into evolutionarily distant bacterial ribosomes. Furthermore, high fidelity translation by octopus ribosomes supports proteomic stability during extensive RNA editing observed in cephalopods, suggesting synergy between distinct non-canonical modes of gene regulation. This adaptation emerged in recently derived octopuses with expanded nervous systems, thereby revealing a mechanism that could broadly support the evolution of novel organismal traits. |
リンク | bioRxiv / PubMed:42395388 / PubMed Central |
| 手法 | EM (単粒子) |
| 解像度 | 3.1 - 3.3 Å |
| 構造データ | ![]() EMDB-48049: Octopus ribosome, empty 80S ![]() EMDB-48050: Octopus ribosome, 60S (multibody) ![]() EMDB-48051: Octopus ribosome, 40S (multibody) EMDB-48061, PDB-9eho: |
| 化合物 | ![]() ChemComp-MG: ![]() ChemComp-SPD: ![]() ChemComp-ZN: |
| 由来 |
|
キーワード | RIBOSOME / Octopus ribosone |
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octopus (無脊椎動物)
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