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TitleHeparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Journal, issue, pagesElife, Vol. 8, Year 2019
Publish dateFeb 5, 2019
AuthorsWenjuan Zhang / Benjamin Falcon / Alexey G Murzin / Juan Fan / R Anthony Crowther / Michel Goedert / Sjors Hw Scheres /
PubMed AbstractAssembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer's and Pick's ...Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer's and Pick's diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments that were assembled from recombinant full-length human tau with four (2N4R) or three (2N3R) microtubule-binding repeats in the presence of heparin. 2N4R tau assembles into multiple types of filaments, and the structures of three types reveal similar 'kinked hairpin' folds, in which the second and third repeats pack against each other. 2N3R tau filaments are structurally homogeneous, and adopt a dimeric core, where the third repeats of two tau molecules pack in a parallel manner. The heparin-induced tau filaments differ from those of Alzheimer's or Pick's disease, which have larger cores with different repeat compositions. Our results illustrate the structural versatility of amyloid filaments, and raise questions about the relevance of in vitro assembly.
External linksElife / PubMed:30720432 / PubMed Central
MethodsEM (helical sym.) / EM (single particle)
Resolution3.3 - 3.7 Å
Structure data

4563

6qjh

EMDB-4563: Cryo-EM reconstruction of heparin-induced 2N4R tau snake filaments
PDB-6qjh: Cryo-EM structure of heparin-induced 2N4R tau snake filaments
Method: EM (helical sym.) / Resolution: 3.3 Å

4564

6qjm

EMDB-4564: Cryo-EM reconstruction of heparin-induced 2N4R tau twister filaments
PDB-6qjm: Cryo-EM structure of heparin-induced 2N4R tau twister filaments
Method: EM (helical sym.) / Resolution: 3.3 Å

4565

6qjp

EMDB-4565: Cryo-EM reconstruction of heparin-induced 2N4R tau jagged filaments
PDB-6qjp: Cryo-EM structure of heparin-induced 2N4R tau jagged filaments
Method: EM (helical sym.) / Resolution: 3.5 Å

4566

6qjq

EMDB-4566: Cryo-EM reconstruction of heparin-induced 2N3R tau filaments
PDB-6qjq: Cryo-EM structure of heparin-induced 2N3R tau filaments
Method: EM (helical sym.) / Resolution: 3.7 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Recombinant tau protein / heparin / filament / cross-beta structure

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