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TitleFunctional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies.
Journal, issue, pagesNat Microbiol, Vol. 9, Issue 8, Page 2128-2143, Year 2024
Publish dateJun 10, 2024
AuthorsNaveenchandra Suryadevara / Ana Rita Otrelo-Cardoso / Nurgun Kose / Yao-Xiong Hu / Elad Binshtein / Rachael M Wolters / Alexander L Greninger / Laura S Handal / Robert H Carnahan / Anne Moscona / Theodore S Jardetzky / James E Crowe /
PubMed AbstractHuman parainfluenza virus type 3 (hPIV3) is a respiratory pathogen that can cause severe disease in older people and infants. Currently, vaccines against hPIV3 are in clinical trials but none have ...Human parainfluenza virus type 3 (hPIV3) is a respiratory pathogen that can cause severe disease in older people and infants. Currently, vaccines against hPIV3 are in clinical trials but none have been approved yet. The haemagglutinin-neuraminidase (HN) and fusion (F) surface glycoproteins of hPIV3 are major antigenic determinants. Here we describe naturally occurring potently neutralizing human antibodies directed against both surface glycoproteins of hPIV3. We isolated seven neutralizing HN-reactive antibodies and a pre-fusion conformation F-reactive antibody from human memory B cells. One HN-binding monoclonal antibody (mAb), designated PIV3-23, exhibited functional attributes including haemagglutination and neuraminidase inhibition. We also delineated the structural basis of neutralization for two HN and one F mAbs. MAbs that neutralized hPIV3 in vitro protected against infection and disease in vivo in a cotton rat model of hPIV3 infection, suggesting correlates of protection for hPIV3 and the potential clinical utility of these mAbs.
External linksNat Microbiol / PubMed:38858594 / PubMed Central
MethodsEM (single particle)
Resolution3.2 - 3.24 Å
Structure data

41505

8tqi

EMDB-41505, PDB-8tqi:
Hemagglutinin-neuraminidase from Human parainfluenza virus type 3: complex with rPIV3-23 and rPIV3-28 Fabs
Method: EM (single particle) / Resolution: 3.24 Å

41506

8tqk

EMDB-41506, PDB-8tqk:
Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab
Method: EM (single particle) / Resolution: 3.2 Å

Source
  • human respirovirus 3
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Immune system / viral neutralization / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex

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