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TitleFilament structures unveil the dynamic organization of human acetyl-CoA carboxylase.
Journal, issue, pagesSci Adv, Vol. 10, Issue 41, Page eado4880, Year 2024
Publish dateOct 11, 2024
AuthorsFayang Zhou / Yuanyuan Zhang / Yuyao Zhu / Qiang Zhou / Yigong Shi / Qi Hu /
PubMed AbstractHuman acetyl-coenzyme A (CoA) carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic ...Human acetyl-coenzyme A (CoA) carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic organization of ACCs is largely unknown. Here, we determined the cryo-electron microscopy (EM) structure of human ACC1 in its inactive state, which forms a unique filament structure and is in complex with acetyl-CoA. We also determined the cryo-EM structure of human ACC1 activated by dephosphorylation and citrate treatment, at a resolution of 2.55 Å. Notably, the covalently linked biotin binds to a site that is distant from the acetyl-CoA binding site when acetyl-CoA is absent, suggesting a potential coordination between biotin binding and acetyl-CoA binding. These findings provide insights into the structural dynamics and regulatory mechanisms of human ACCs.
External linksSci Adv / PubMed:39383219 / PubMed Central
MethodsEM (single particle)
Resolution2.55 - 4.14 Å
Structure data

38432

8xkz

EMDB-38432, PDB-8xkz:
Core region of the citrate-induced human acetyl-CoA carboxylase 1 filament (ACC1-citrate)
Method: EM (single particle) / Resolution: 2.55 Å

38433

8xl0

EMDB-38433, PDB-8xl0:
Citrate-induced filament of human acetyl-coenzyme A carboxylase 1 (ACC1-citrate)
Method: EM (single particle) / Resolution: 4.14 Å

38434

8xl1

EMDB-38434, PDB-8xl1:
Core region of the human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)
Method: EM (single particle) / Resolution: 2.57 Å

38435

8xl2

EMDB-38435, PDB-8xl2:
Human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)
Method: EM (single particle) / Resolution: 2.73 Å

Chemicals

ChemComp-BTN:
BIOTIN

ChemComp-ACO:
ACETYL COENZYME *A

Source
  • homo sapiens (human)
KeywordsLIGASE / Biotin-dependent carboxylase

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