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Structure paper

TitleStructures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage.
Journal, issue, pagesNat Commun, Vol. 11, Issue 1, Page 4421, Year 2020
Publish dateSep 4, 2020
AuthorsKang Wang / Ling Zhu / Yao Sun / Minhao Li / Xin Zhao / Lunbiao Cui / Li Zhang / George F Gao / Weiwei Zhai / Fengcai Zhu / Zihe Rao / Xiangxi Wang /
PubMed AbstractReceptor usage that determines cell tropism and drives viral classification closely correlates with the virus structure. Enterovirus B (EV-B) consists of several subgroups according to receptor ...Receptor usage that determines cell tropism and drives viral classification closely correlates with the virus structure. Enterovirus B (EV-B) consists of several subgroups according to receptor usage, among which echovirus 30 (E30), a leading causative agent for human aseptic meningitis, utilizes FcRn as an uncoating receptor. However, receptors for many EVs remain unknown. Here we analyzed the atomic structures of E30 mature virion, empty- and A-particles, which reveals serotype-specific epitopes and striking conformational differences between the subgroups within EV-Bs. Of these, the VP1 BC loop markedly distinguishes E30 from other EV-Bs, indicative of a role as a structural marker for EV-B. By obtaining cryo-electron microscopy structures of E30 in complex with its receptor FcRn and CD55 and comparing its homologs, we deciphered the underlying molecular basis for receptor recognition. Together with experimentally derived viral receptor identifications, we developed a structure-based in silico algorithm to inform a rational prediction for EV receptor usage.
External linksNat Commun / PubMed:32887891 / PubMed Central
MethodsEM (single particle)
Resolution2.9 - 3.6 Å
Structure data

30315

7c9s

EMDB-30315, PDB-7c9s:
Echovirus 30 F-particle
Method: EM (single particle) / Resolution: 2.9 Å

30316

7c9t

EMDB-30316, PDB-7c9t:
Echovirus 30 A-particle
Method: EM (single particle) / Resolution: 2.9 Å

30317

7c9u

EMDB-30317, PDB-7c9u:
Echovirus 30 E-particle
Method: EM (single particle) / Resolution: 3.4 Å

30318

7c9v

EMDB-30318, PDB-7c9v:
E30 F-particle in complex with FcRn
Method: EM (single particle) / Resolution: 3.3 Å

30319

7c9w

EMDB-30319, PDB-7c9w:
E30 F-particle in complex with CD55
Method: EM (single particle) / Resolution: 3.6 Å

30320

7c9x

EMDB-30320, PDB-7c9x:
Echovirus 3 F-particle
Method: EM (single particle) / Resolution: 3.4 Å

30321

7c9y

EMDB-30321, PDB-7c9y:
Coxsackievirus B5 (CVB5) F-particle
Method: EM (single particle) / Resolution: 3.5 Å

30322

7c9z

EMDB-30322, PDB-7c9z:
Coxsackievirus B1 F-particle
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

ChemComp-SPH:
SPHINGOSINE / Sphingosine

ChemComp-MYR:
MYRISTIC ACID / Myristic acid

ChemComp-PLM:
PALMITIC ACID / Palmitic acid

Source
  • echovirus e30
  • homo sapiens (human)
  • echovirus e3
  • coxsackievirus b5
  • coxsackievirus b1
KeywordsVIRUS / Echovirus B / mature / altered particle / premature / receptor / Echovirus 30 / attachement receptor

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