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Structure paper

TitleInterplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor
Journal, issue, pagesNat Commun, Vol. 15, Page 4115, Year 2024
Publish dateSep 5, 2020 (structure data deposition date)
AuthorsNayak AR / Rangubpit W / Will AH / Hu Y / Castro-Hartmann P / Lobo JJ / Dryden K / Lamb GD / Sompornpisut P / Samso M
External linksNat Commun / Search PubMed
MethodsEM (single particle)
Resolution3.09 - 4.5 Å
Structure data

22615

7k0s

EMDB-22615, PDB-7k0s:
Cryo-EM structure of rabbit RyR1 in the presence of Mg2+ and AMP-PCP in nanodisc
Method: EM (single particle) / Resolution: 4.5 Å

26610

7umz

EMDB-26610, PDB-7umz:
Cryo-EM structure of rabbit RyR1 in the presence of high Mg2+ and AMP-PCP in nanodisc
Method: EM (single particle) / Resolution: 3.09 Å

Chemicals

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-LBN:
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine / phospholipid*YM

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSPORT PROTEIN / Ryanodine Receptor / RyR1 / Intracellular Calcium channel / Mg2+ / Inhibition / Excitation-Contraction coupling

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