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TitleHIV-1 vaccine induction of protective tier 2 neutralizing antibodies in nonhuman primates is augmented by TLR7/8 agonism
Journal, issue, pagesTo Be Published
Publish dateMay 15, 2021 (structure data deposition date)
AuthorsTilahun K / Manne K / Edwards RJ / Lu X / Mansouri K / Hernandez G / Sutherland L / Scearce R / Parks R / Barr M ...Tilahun K / Manne K / Edwards RJ / Lu X / Mansouri K / Hernandez G / Sutherland L / Scearce R / Parks R / Barr M / DeMarco T / Eater C / Eaton A / Wang Y / Rountree RW / Tomai M / Fox C / Moody MA / Alam M / Denny T / Shaw G / Montefiori DC / Acharya P / Saunders KO / Haynes BF
External linksSearch PubMed
MethodsEM (single particle)
Resolution4.8 - 18.4 Å
Structure data

EMDB-24065: CryoEM map of monoclonal antibody Fab DH1025.1 bound to bound to CH505.M5 SOSIP trimer
Method: EM (single particle) / Resolution: 4.8 Å

EMDB-24619:
Negative stain electron microscopy single particle reconstruction of monoclonal antibody DH1024 Fab in complex with HIV-1 Env CH505 SOSIP trimer
Method: EM (single particle) / Resolution: 15.0 Å

EMDB-24620:
Negative stain electron microscopy single particle reconstruction of monoclonal antibody DH1025.1 Fab in complex with HIV-1 Env CH505 SOSIP trimer
Method: EM (single particle) / Resolution: 10.4 Å

EMDB-24621:
Negative stain electron microscopy single particle reconstruction of monoclonal antibody DH1027 Fab in complex with HIV-1 Env CH505 SOSIP trimer.
Method: EM (single particle) / Resolution: 18.4 Å

EMDB-24622:
Negative stain electron microscopy single particle reconstruction of monoclonal antibody DH1028 Fab in complex with HIV-1 Env CH505 SOSIP trimer.
Method: EM (single particle) / Resolution: 12.9 Å

EMDB-24623:
Negative stain electron microscopy single particle reconstruction of monoclonal antibody DH950 Fab in complex with HIV-1 Env CH505 SOSIP trimer.
Method: EM (single particle) / Resolution: 15.4 Å

Source
  • Human immunodeficiency virus 1
  • Homo sapiens (human)
  • Human immunodeficiency virus 2
  • Macaca mulatta (Rhesus monkey)

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