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TitleAtomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes.
Journal, issue, pagesNat Commun, Vol. 10, Issue 1, Page 5346, Year 2019
Publish dateNov 25, 2019
AuthorsYibo Zhang / Wei Liu / Zihang Li / Vinay Kumar / Ana L Alvarez-Cabrera / Emily C Leibovitch / Yanxiang Cui / Ye Mei / Guo-Qiang Bi / Steve Jacobson / Z Hong Zhou /
PubMed AbstractHuman herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae. To understand capsid assembly and capsid-tegument interactions, here we report atomic structures of HHV-6B ...Human herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae. To understand capsid assembly and capsid-tegument interactions, here we report atomic structures of HHV-6B capsid and capsid-associated tegument complex (CATC) obtained by cryoEM and sub-particle reconstruction. Compared to other β-herpesviruses, HHV-6B exhibits high similarity in capsid structure but organizational differences in its CATC (pU11 tetramer). 180 "VΛ"-shaped CATCs are observed in HHV-6B, distinguishing from the 255 "Λ"-shaped dimeric CATCs observed in murine cytomegalovirus and the 310 "Δ"-shaped CATCs in human cytomegalovirus. This trend in CATC quantity correlates with the increasing genomes sizes of these β-herpesviruses. Incompatible distances revealed by the atomic structures rationalize the lack of CATC's binding to triplexes Ta, Tc, and Tf in HHV-6B. Our results offer insights into HHV-6B capsid assembly and the roles of its tegument proteins, including not only the β-herpesvirus-specific pU11 and pU14, but also those conserved across all subfamilies of Herpesviridae.
External linksNat Commun / PubMed:31767868 / PubMed Central
MethodsEM (single particle)
Resolution3.77 - 9.0 Å
Structure data

20557

6q1f

EMDB-20557, PDB-6q1f:
Atomic structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Method: EM (single particle) / Resolution: 9.0 Å

EMDB-20558:
Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Method: EM (single particle) / Resolution: 3.77 Å

EMDB-20559:
Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Method: EM (single particle) / Resolution: 3.82 Å

EMDB-20560:
Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Method: EM (single particle) / Resolution: 3.77 Å

Source
  • human herpesvirus 6b (strain z29)
KeywordsVIRUS / beta-herpesvirus / HHV-6B / murine cytomegalovirus / human cytomegalovirus / pp150 / pU11 / pUL32 / pM32 / pU14

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