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-Structure paper
Title | Structural basis for inhibition of beta-FXIIa by garadacimab |
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Journal, issue, pages | To Be Published |
Publish date | Nov 29, 2023 (structure data deposition date) |
Authors | Drulyte I / Ghai R / Ow SY / Kapp EA / Quek AJ / Panousis C / Wilson MJ / Nash AD / Pelzing M |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 2.6 - 3.9 Å |
Structure data | EMDB-18999, PDB-8r8d: EMDB-19000: Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (asymmetric dimer) EMDB-19001: Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (monomer) |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | BLOOD CLOTTING / Complex / coagulation / trypsin-like serine protease / hereditary angioedema (HAE) |