+Search query
-Structure paper
Title | A resurrected ancestor of Cas12a expands target access and substrate 2 recognition for nucleic-acid editing and detection |
---|---|
Journal, issue, pages | Nature Biotechnology, Year 2024 |
Publish date | Oct 19, 2023 (structure data deposition date) |
Authors | Jabalera Y / Tascon I / Samperio S / Lopez-Alonso JP / Gonzalez-Lopez M / Aransay AM / Abascal-Palacios G / Beisel CL / Ubarretxena-Belandia I / Jimenez-Perez R |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 3.08 - 3.75 Å |
Structure data | EMDB-18691, PDB-8qwd: EMDB-18692: Apo ReChb , Rec1 improved EMDB-18693, PDB-8qwe: EMDB-18694: Quaternary complex of ReChb - crRNA - target dsDNA - collateral dsDNA |
Chemicals | ChemComp-MG: ChemComp-HOH: |
Source |
|
Keywords | BIOSYNTHETIC PROTEIN / Cas / cryo-EM / ancestral sequence reconstruction / biotechnology / DNA / RNA |