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-Structure paper
Title | Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex |
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Journal, issue, pages | To Be Published |
Publish date | Jul 20, 2023 (structure data deposition date) |
Authors | Ruedas R / Vuillemot R / Tubiana T / Winter JM / Pieri L / Arteni AA / Samson C / Jonic J / Mathieu M / Bressanelli S |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 3.01 - 3.33 Å |
Structure data | EMDB-17993, PDB-8pwh: EMDB-18188, PDB-8q6j: EMDB-18189: Cryo-EM map of the pertuzumab-HER2 complex obtained from local refinement of the HER2-pertuzumab-trastuzumab ternary complex EMDB-18190: Cryo-EM map of the trastuzumab-HER2 complex obtained from local refinement of the HER2-pertuzumab-trastuzumab ternary complex |
Chemicals | ChemComp-NAG: |
Source |
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Keywords | STRUCTURAL PROTEIN / ErbB-2 / Pertuzumab / Trastuzumab / Ternary complex / Protein / Flexibility / Continuous conformation / Cryo-EM / Single particle analysis |