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Structure paper

TitleSubstrate Transport and Specificity in a Phospholipid Flippase
Journal, issue, pagesTo Be Published
Publish dateAug 10, 2021 (structure data deposition date)
AuthorsWang Y / Lyons JA / Timcenko M / Kummerer F / de Groot BL / Nissen P / Gapsys V / Lindorff-Larsen K
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 Å
Structure data

13353

7pem

EMDB-13353: Phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state
PDB-7pem: Cryo-EM structure of phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-2Y5:
(2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate

ChemComp-MG:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-Q3G:
O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine / phospholipid*YM

ChemComp-HOH:
WATER

Source
  • Saccharomyces cerevisiae (brewer's yeast)
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
KeywordsMEMBRANE PROTEIN / Lipid Flippase / P4 ATPase / trans-Golgi Network / Phosphatidylserine transport

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