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-Structure paper
Title | ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane. |
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Journal, issue, pages | Nat Struct Mol Biol, Vol. 12, Issue 11, Page 1015-1016, Year 2005 |
Publish date | May 31, 2006 |
Authors | Michael Blau / Srinivas Mullapudi / Thomas Becker / Johanna Dudek / Richard Zimmermann / Pawel A Penczek / Roland Beckmann / |
PubMed Abstract | Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). ...Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). Recently, a new RAMP, ERj1p, has been identified that recruits BiP to ribosomes and regulates translational activity. Here we present the cryo-EM structure of a ribosome-ERj1p complex, revealing how ERj1p coordinates the ribosome at the membrane and how allosteric effects may mediate ERj1p's regulatory activity. |
External links | Nat Struct Mol Biol / PubMed:16244660 |
Methods | EM (single particle) |
Resolution | 20.0 - 23.0 Å |
Structure data | EMDB-1168: EMDB-1169: |
Source |
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