EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 67, Page 18993-19009, Year 2024
掲載日	2024年5月29日 (構造データの登録日)
著者	Vasas, A. / Ivanschitz, L. / Molnar, B. / Kiss, A. / Baker, L. / Fiumana, A. / Macias, A. / Murray, J.B. / Sanders, E. / Whitehead, N. ...Vasas, A. / Ivanschitz, L. / Molnar, B. / Kiss, A. / Baker, L. / Fiumana, A. / Macias, A. / Murray, J.B. / Sanders, E. / Whitehead, N. / Hubbard, R.E. / Saunier, C. / Monceau, E. / Girard, A.M. / Rousseau, M. / Chanrion, M. / Demarles, D. / Geneste, O. / Weber, C. / Lewkowicz, E. / Kotschy, A.
リンク	J. Med. Chem. / PubMed:39441669
手法	X線回折
解像度	2.6 - 3.37 Å
構造データ	PDB-9fio: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-9fip: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 3.06 Å PDB-9fiq: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 2.86 Å PDB-9fir: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 2.76 Å PDB-9fis: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 2.77 Å PDB-9fit: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-9fiu: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 3.37 Å PDB-9fiv: Structure-guided discovery of selective USP7 inhibitors with in vivo activity 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å
化合物	ChemComp-R4D: 3-({4-hydroxy-1-[(2R)-2-methyl-3-phenylpropanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one ChemComp-HOH: WATER PDB-1icu: THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID PDB-1icv: THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID PDB-1ics: CRYSTAL STRUCTURE OF 12-OXOPHYTODIENOATE REDUCTASE 1 FROM TOMATO PDB-1icw: INTERLEUKIN-8, MUTANT WITH GLU 38 REPLACED BY CYS AND CYS 50 REPLACED BY ALA PDB-1ict: MONOCLINIC FORM OF HUMAN TRANSTHYRETIN COMPLEXED WITH THYROXINE (T4) PDB-1icx: CRYSTAL STRUCTURE OF PATHOGENESIS-RELATED PROTEIN LLPR10.1A FROM YELLOW LUPINE PDB-1ico: SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / HAUSP / USP7 / SBDD / HYDROLASE-HYDROLASE INHIBITOR COMPLEX