タイトル | Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. |
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ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Year 2024 |
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掲載日 | 2024年5月1日 (構造データの登録日) |
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著者 | Roske JJ / Yeeles JTP |
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リンク | Nat. Struct. Mol. Biol. / PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 3.3 - 4.2 Å |
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構造データ | EMDB-50222, PDB-9f6d: Human DNA polymerase epsilon bound to DNA and PCNA (open conformation) 手法: EM (単粒子) / 解像度: 3.6 Å EMDB-50223, PDB-9f6e: Human DNA polymerase epsilon bound to DNA and PCNA (ajar conformation) 手法: EM (単粒子) / 解像度: 3.74 Å EMDB-50224, PDB-9f6f: Human DNA polymerase epsilon bound to DNA and PCNA (closed conformation) 手法: EM (単粒子) / 解像度: 3.75 Å EMDB-50225, PDB-9f6i: Human DNA Polymerase epsilon bound to T-C mismatched DNA (Post-Insertion state) 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-50226, PDB-9f6j: Human DNA Polymerase epsilon bound to T-C mismatched DNA (Polymerase Arrest state) 手法: EM (単粒子) / 解像度: 3.9 Å EMDB-50227, PDB-9f6k: Human DNA Polymerase epsilon bound to T-C mismatched DNA (Frayed Substrate state) 手法: EM (単粒子) / 解像度: 4.2 Å EMDB-50228, PDB-9f6l: Human DNA Polymerase epsilon bound to T-C mismatched DNA (Mismatch Excision state) 手法: EM (単粒子) / 解像度: 3.9 Å |
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化合物 | |
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由来 | homo sapiens (ヒト)- synthetic construct (人工物)
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キーワード | REPLICATION / DNA / polymerase / epsilon / PCNA / leading strand / human / replisome / proofreading |
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