タイトル | Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides. |
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ジャーナル・号・ページ | Nat Commun, Vol. 14, Page 7842-7842, Year 2023 |
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掲載日 | 2023年3月14日 (構造データの登録日) |
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著者 | Hansen, M.H. / Adamek, M. / Iftime, D. / Petras, D. / Schuseil, F. / Grond, S. / Stegmann, E. / Cryle, M.J. / Ziemert, N. |
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リンク | Nat Commun / PubMed:38030603 |
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手法 | X線回折 |
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解像度 | 1.64 - 3.12 Å |
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構造データ | PDB-8gic: A1 Tei + Hpg: Adenylation domain 1 core construct from teicoplanin biosynthesis; 4-hydroxyphenylglycine bound 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-8gj4: A1 Tei: Adenylation domain 1 core construct from teicoplanin biosynthesis 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-8gjp: A1 Int graft: Adenylation domain 1 core construct from teicoplanin biosynthesis, intermediate selection pocket graft 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-8gkm: A1 Leu graft + Leu: Adenylation domain 1 core construct from teicoplanin biosynthesis, leucine selection pocket graft; leucine bound 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-8glc: A1 AncAla: Adenylation domain 1 core construct from ancestral reconstruction of glycopeptide antibiotic biosynthesis, alanine selection pocket 手法: X-RAY DIFFRACTION / 解像度: 3.12 Å |
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化合物 | |
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由来 | actinoplanes teichomyceticus (バクテリア) actinoplanes (バクテリア)
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キーワード | LIGASE / AMP-binding enzyme / NRPS / Adenylation domain |
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