タイトル | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 119, Page e2210114119-e2210114119, Year 2022 |
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掲載日 | 2022年6月6日 (構造データの登録日) |
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著者 | Chen, Z. / Zakrzewska, S. / Hajare, H.S. / Alvarez-Buylla, A. / Abderemane-Ali, F. / Bogan, M. / Ramirez, D. / O'Connell, L.A. / Du Bois, J. / Minor Jr., D.L. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:36279441 |
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手法 | X線回折 |
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解像度 | 2 - 2.7 Å |
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構造データ | PDB-8d6g: Nanorana parkeri saxiphilin 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8d6m: Nanorana parkeri saxiphilin:STX (co-crystal) 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-8d6o: Nanorana parkeri saxiphilin:F-STX (soaked) 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8d6p: Rana catesbeiana saxiphilin mutant - Y558A 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-8d6q: Rana catesbeiana saxiphilin mutant - Y558I 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-8d6s: Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-8d6t: Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-8d6u: Rana catesbeiana saxiphilin:F-STX (soaked) 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å |
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化合物 | ChemComp-9SL: [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate / サキシトキシン / 神経毒*YM
ChemComp-QDX: (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid
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由来 | - nanorana parkeri (カエル)
- lithobates catesbeianus (カエル)
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キーワード | ANTITOXIN / Saxiphilin / Toxin resistance / Saxitoxin |
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