タイトル | A general chemical principle for creating closure-stabilizing integrin inhibitors. |
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ジャーナル・号・ページ | Cell, Vol. 185, Page 3533-3550.e27, Year 2022 |
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掲載日 | 2020年12月31日 (構造データの登録日) |
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著者 | Lin, F.Y. / Li, J. / Xie, Y. / Zhu, J. / Huong Nguyen, T.T. / Zhang, Y. / Springer, T.A. |
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リンク | Cell / PubMed:36113427 |
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手法 | X線回折 |
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解像度 | 1.99998841007 - 2.99768170407 Å |
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構造データ | PDB-7l8p: Integrin alphaIIbbeta3 in complex with sibrafiban 手法: X-RAY DIFFRACTION / 解像度: 2.3499537016 Å PDB-7tct: Integrin alaphIIBbeta3 complex with UR2922 手法: X-RAY DIFFRACTION / 解像度: 2.501 Å PDB-7td8: Integrin alaphIIBbeta3 complex with Tirofiban 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7tho: Integrin alaphIIBbeta3 complex with Eptifibatide 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-7tmz: Integrin alaphIIBbeta3 complex with BMS compound 4 手法: X-RAY DIFFRACTION / 解像度: 2.20001999293 Å PDB-7tpd: Integrin alaphIIBbeta3 complex with EF5154 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7u60: Integrin alaphIIBbeta3 complex with cRGDfV 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-7u9f: Integrin alaphIIBbeta3 complex with BMS compound 4 in Mn2+ 手法: X-RAY DIFFRACTION / 解像度: 2.70000525883 Å PDB-7u9v: Integrin alaphIIBbeta3 complex with BMS4-1 手法: X-RAY DIFFRACTION / 解像度: 2.25492157575 Å PDB-7ubr: Integrin alaphIIBbeta3 complex with GR144053 手法: X-RAY DIFFRACTION / 解像度: 2.04992751372 Å PDB-7ucy: Integrin alaphIIBbeta3 complex with gantofiban 手法: X-RAY DIFFRACTION / 解像度: 2.34996314573 Å PDB-7udg: Integrin alaphIIBbeta3 complex with lotrafiban 手法: X-RAY DIFFRACTION / 解像度: 2.80006901797 Å PDB-7udh: Integrin alaphIIBbeta3 complex with BMS4-3 手法: X-RAY DIFFRACTION / 解像度: 1.99998841007 Å PDB-7ue0: Integrin alaphIIBbeta3 complex with fradafiban 手法: X-RAY DIFFRACTION / 解像度: 2.74196193977 Å PDB-7ufh: Integrin alaphIIBbeta3 complex with fradafiban (Mn/Ca) 手法: X-RAY DIFFRACTION / 解像度: 2.99768170407 Å PDB-7uh8: Integrin alaphIIBbeta3 complex with roxifiban (Mn/Ca) 手法: X-RAY DIFFRACTION / 解像度: 2.75002413567 Å PDB-7uje: Integrin alaphIIBbeta3 complex with UR2922 in Mn2+ 手法: X-RAY DIFFRACTION / 解像度: 2.4999681528 Å PDB-7ujk: Integrin alaphIIBbeta3 complex with lamifiban 手法: X-RAY DIFFRACTION / 解像度: 2.43265583434 Å PDB-7uk9: Integrin alaphIIBbeta3 complex with lamifiban (Mn) 手法: X-RAY DIFFRACTION / 解像度: 2.60001966299 Å PDB-7uko: Integrin alaphIIBbeta3 complex with sibrafiban (Mn) 手法: X-RAY DIFFRACTION / 解像度: 2.604 Å PDB-7ukp: Integrin alaphIIBbeta3 complex with a gantofiban analog 手法: X-RAY DIFFRACTION / 解像度: 2.80112979054 Å PDB-7ukt: Integrin alaphIIBbeta3 complex with BMS4.2 手法: X-RAY DIFFRACTION / 解像度: 2.36994437552 Å |
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化合物 | ChemComp-I1F: {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid
ChemComp-I7R: (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid
ChemComp-IR7: (4-{[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl}phenoxy)acetic acid
ChemComp-M6K: (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid
ChemComp-MV8: (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid
ChemComp-MWO: (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid
ChemComp-NJ9: 3-(4-{[(5S)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)propanoic acid
ChemComp-NJF: (1-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperidin-4-yl)acetic acid
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由来 | homo sapiens (ヒト)![](img/tx_mammal.gif) mus musculus (ハツカネズミ)- synthetic construct (人工物)
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キーワード | CELL ADHESION / platelet aggregation / MEMBRANE PROTEIN-IMMUNE SYSTEM complex / integrin inhibitor / RGD mimetics / BLOOD CLOTTING/INHIBITOR / Complex / Inhibitor / BLOOD CLOTTING / BLOOD CLOTTING-INHIBITOR complex / CELL ADHESION/INHIBITOR / CELL ADHESION-INHIBITOR complex |
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