タイトル | Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis. |
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ジャーナル・号・ページ | Acs Infect Dis., Vol. 8, Page 1231-1240, Year 2022 |
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掲載日 | 2021年12月13日 (構造データの登録日) |
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著者 | Sacco, M.D. / Defrees, K. / Zhang, X. / Lawless, W. / Nwanochie, E. / Balsizer, A. / Darch, S.E. / Renslo, A.R. / Chen, Y. |
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リンク | Acs Infect Dis. / PubMed:35653508 |
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手法 | X線回折 |
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解像度 | 1.95 - 3 Å |
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構造データ | PDB-7t5r: P. aeruginosa LpxA in complex with ligand H7 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7t5s: P. aeruginosa LpxA in complex with ligand H16 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-7t5x: P. aeruginosa LpxA in complex with ligand L6 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-7t5z: P. aeruginosa LpxA in complex with ligand L8 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-7t60: P. aeruginosa LpxA in complex with ligand L13 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7t61: P. aeruginosa LpxA in complex with ligand L15 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-F30: 3-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]-1H-indole-5-carboxamide
ChemComp-F3R: N~2~-(cyclohexylacetyl)-N-1H-tetrazol-5-yl-L-alaninamide
ChemComp-F4L: Nalpha-(tert-butoxycarbonyl)-N-1H-tetrazol-5-yl-D-tryptophanamide
ChemComp-F6I: (4S)-N-(1H-tetrazol-5-yl)-2-[3-(trifluoromethyl)benzene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide
ChemComp-F9H: (3S)-3-(5,5-dimethyl-2-oxo-1,3-oxazolidin-3-yl)-N-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)benzoyl]-2,3-dihydro-1H-indole-3-carboxamide
ChemComp-FCU: (3S)-3-({[(Z)-phenylmethylidene]carbamoyl}amino)-N-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)benzoyl]-2,3-dihydro-1H-indole-3-carboxamide
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由来 | - pseudomonas aeruginosa pa7 (緑膿菌)
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キーワード | TRANSFERASE / Lpxa / lipid A / LPS / lipopolysaccharide / UDP-N-acetylglucosamine O-acyltransferase |
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