タイトル | Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA. |
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ジャーナル・号・ページ | Epigenetics, Vol. 17, Page 970-981, Year 2022 |
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掲載日 | 2021年7月14日 (構造データの登録日) |
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著者 | Zhou, J. / Horton, J.R. / Yu, D. / Ren, R. / Blumenthal, R.M. / Zhang, X. / Cheng, X. |
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リンク | Epigenetics / PubMed:34523387 |
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手法 | X線回折 |
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解像度 | 2.05 - 2.68 Å |
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構造データ | PDB-7rfk: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor Sinefungin 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-7rfl: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor SGC0946 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-7rfm: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor EPZ004777 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-7rfn: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor SGC8158 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-AW2: 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine
ChemComp-0QK: 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine / EPZ-004777
ChemComp-MJ7: 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine
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由来 | clostridioides difficile (バクテリア)
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キーワード | DNA BINDING PROTEIN/DNA / DNA Adenine Methylation / PROTEIN-DNA COMPLEX / TRANSFERASE / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex |
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