EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
ジャーナル・号・ページ	J. Med. Chem., Vol. 65, Page 11574-11606, Year 2022
掲載日	2021年3月11日 (構造データの登録日)
著者	Iannelli, G. / Milite, C. / Marechal, N. / Cura, V. / Bonnefond, L. / Troffer-Charlier, N. / Feoli, A. / Rescigno, D. / Wang, Y. / Cipriano, A. ...Iannelli, G. / Milite, C. / Marechal, N. / Cura, V. / Bonnefond, L. / Troffer-Charlier, N. / Feoli, A. / Rescigno, D. / Wang, Y. / Cipriano, A. / Viviano, M. / Bedford, M.T. / Cavarelli, J. / Castellano, S. / Sbardella, G.
リンク	J. Med. Chem. / PubMed:35482954
手法	X線回折
解像度	1.65 - 2.42 Å
構造データ	PDB-7nud: Crystal structure of mouse PRMT6 in complex with inhibitor EML734 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-7nue: Crystal structure of mouse PRMT6 in complex with inhibitor EML736 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-7p2r: Crystal structure of mouse PRMT6 in complex with inhibitor EML980 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7ppq: CARM1 in complex with EML736 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-7ppy: CARM1 in complex with EML709 手法: X-RAY DIFFRACTION / 解像度: 2.42 Å PDB-7pu8: CARM1 in complex with EML980 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-7puc: CARM1 in complex with EML981 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-7puq: CARM1 in complex with EML982 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-7pv6: CARM1 in complex with EML734 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å
化合物	ChemComp-LRZ: methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate ChemComp-HOH: WATER ChemComp-LSK: methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate ChemComp-4R7: methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate ChemComp-SAH: S-ADENOSYL-L-HOMOCYSTEINE / S-アデノシルホモシステイン ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-7ZH: methyl 6-[4-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate ChemComp-85U: methyl 6-[4-[[~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate ChemComp-867: methyl 6-[4-[[~{N}-[3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate ChemComp-PG4: TETRAETHYLENE GLYCOL / テトラエチレングリコ-ル / 沈殿剤*YM
由来	mus musculus (ハツカネズミ)
キーワード	TRANSFERASE / SAM binding domain / arginine methylation / TRANSCRIPTION / protein arginine N-methyltransferase / PRMT4 / CARM1 / inhibitor