EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-based classification of tauopathies.
ジャーナル・号・ページ	Nature, Vol. 598, Issue 7880, Page 359-363, Year 2021
掲載日	2021年9月29日
著者	Yang Shi / Wenjuan Zhang / Yang Yang / Alexey G Murzin / Benjamin Falcon / Abhay Kotecha / Mike van Beers / Airi Tarutani / Fuyuki Kametani / Holly J Garringer / Ruben Vidal / Grace I Hallinan / Tammaryn Lashley / Yuko Saito / Shigeo Murayama / Mari Yoshida / Hidetomo Tanaka / Akiyoshi Kakita / Takeshi Ikeuchi / Andrew C Robinson / David M A Mann / Gabor G Kovacs / Tamas Revesz / Bernardino Ghetti / Masato Hasegawa / Michel Goedert / Sjors H W Scheres /
PubMed 要旨	The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the ...The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration are distinct. Here we show that the structures of tau filaments from progressive supranuclear palsy (PSP) define a new three-layered fold. Moreover, the structures of tau filaments from globular glial tauopathy are similar to those from PSP. The tau filament fold of argyrophilic grain disease (AGD) differs, instead resembling the four-layered fold of corticobasal degeneration. The AGD fold is also observed in ageing-related tau astrogliopathy. Tau protofilament structures from inherited cases of mutations at positions +3 or +16 in intron 10 of MAPT (the microtubule-associated protein tau gene) are also identical to those from AGD, suggesting that relative overproduction of four-repeat tau can give rise to the AGD fold. Finally, the structures of tau filaments from cases of familial British dementia and familial Danish dementia are the same as those from cases of Alzheimer's disease and primary age-related tauopathy. These findings suggest a hierarchical classification of tauopathies on the basis of their filament folds, which complements clinical diagnosis and neuropathology and also allows the identification of new entities-as we show for a case diagnosed as PSP, but with filament structures that are intermediate between those of globular glial tauopathy and PSP.
リンク	Nature / PubMed:34588692 / PubMed Central
手法	EM (らせん対称)
解像度	1.9 - 3.4 Å
構造データ	13218 7p65 EMDB-13218, PDB-7p65: Progressive supranuclear palsy tau filament 手法: EM (らせん対称) / 解像度: 2.7 Å 13219 7p66 EMDB-13219, PDB-7p66: Globular glial tauopathy type 1 tau filament 手法: EM (らせん対称) / 解像度: 3.0 Å 13220 7p67 EMDB-13220, PDB-7p67: Globular glial tauopathy type 2 tau filament 手法: EM (らせん対称) / 解像度: 3.1 Å 13221 7p68 EMDB-13221, PDB-7p68: Globular glial tauopathy type 3 tau filament 手法: EM (らせん対称) / 解像度: 2.9 Å 13223 7p6a EMDB-13223, PDB-7p6a: Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament 手法: EM (らせん対称) / 解像度: 1.9 Å 13224 7p6b EMDB-13224, PDB-7p6b: Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament 手法: EM (らせん対称) / 解像度: 2.2 Å 13225 7p6c EMDB-13225, PDB-7p6c: Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament 手法: EM (らせん対称) / 解像度: 2.5 Å 13226 7p6d EMDB-13226, PDB-7p6d: Argyrophilic grain disease type 1 tau filament 手法: EM (らせん対称) / 解像度: 3.3 Å 13227 7p6e EMDB-13227, PDB-7p6e: Argyrophilic grain disease type 2 tau filament 手法: EM (らせん対称) / 解像度: 3.4 Å
化合物	ChemComp-HOH: WATER
由来	homo sapiens (ヒト)
キーワード	PROTEIN FIBRIL / Amyloid fibril