Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
PDB-7mqp: E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228) 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å
PDB-7myl: Crystal structure of DfrA1 dihydrofolate reductase in complex with TRIMETHOPRIM 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å
PDB-7mym: Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH 手法: X-RAY DIFFRACTION / 解像度: 3.04 Å
PDB-7nae: Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å
PDB-7r6g: Crystal structure of DfrA5 dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å
PDB-7reb: E. coli dihydrofolate reductase complexed with 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223) 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å
PDB-7reg: DfrA1 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228) 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å
PDB-7rgj: DfrA1 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223) 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å
PDB-7rgk: DfrA5 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223) 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å
PDB-7rgo: DfrA5 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228) 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å