タイトル | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. |
---|
ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 60, Page 22925-22932, Year 2021 |
---|
掲載日 | 2020年11月25日 (構造データの登録日) |
---|
著者 | Giurgiu, C. / Fang, Z. / Aitken, H.R.M. / Kim, S.C. / Pazienza, L. / Mittal, S. / Szostak, J.W. |
---|
リンク | Angew. Chem. Int. Ed. Engl. / PubMed:34428345 |
---|
手法 | X線回折 |
---|
解像度 | 1.44 - 2.281 Å |
---|
構造データ | PDB-7kuk: High resolution RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å PDB-7kul: DNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-7kum: LNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.714 Å PDB-7kun: 2'-F modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-7kuo: FANA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 2.281 Å PDB-7kup: 2'-OMe modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å PDB-7lne: ANA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-7lnf: 3'-deoxy modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 1.652 Å PDB-7lng: TNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
---|
化合物 | ChemComp-LCC: [(1R,3R,4R,7S)-7-HYDROXY-3-(5-METHYLCYTOSIN-1-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL DIHYDROGEN PHOSPHATE
ChemComp-LCG: [(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL DIHYDROGEN PHOSPHATE
ChemComp-LKC: 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE
ChemComp-TG: 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one
|
---|
由来 | - synthetic construct (人工物)
|
---|
キーワード | RNA / nonenzymatic RNA extension / DNA |
---|