タイトル | Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. |
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ジャーナル・号・ページ | Biochemistry, Vol. 60, Page 1243-1247, Year 2021 |
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掲載日 | 2020年8月26日 (構造データの登録日) |
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著者 | Kholodar, S.A. / Finer-Moore, J.S. / Swiderek, K. / Arafet, K. / Moliner, V. / Stroud, R.M. / Kohen, A. |
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リンク | Biochemistry / PubMed:33829766 |
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手法 | X線回折 |
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解像度 | 1.5 - 1.82 Å |
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構造データ | PDB-7jx1: E. coli TSase complex with a bi-substrate reaction intermediate analog 手法: X-RAY DIFFRACTION / 解像度: 1.82 Å PDB-7jxf: E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å |
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化合物 | ChemComp-VLA: N-(4-{[(2,4-diamino-7,8-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino}benzene-1-carbonyl)-L-glutamic acid
ChemComp-VLD: (2S)-2-({4-[({(6R)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name)
ChemComp-VMV: N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid
ChemComp-VNM: (2S)-2-({4-[({(6S)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name)
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由来 | ![](img/tx_bacteria.gif) escherichia coli (大腸菌)
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キーワード | BIOSYNTHETIC PROTEIN / non covalent intermediate / half-sites activity / TMP synthesis / inhibitor |
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