タイトル | A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 433, Page 166960-166960, Year 2021 |
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掲載日 | 2020年9月14日 (構造データの登録日) |
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著者 | Huang, K.F. / Huang, J.S. / Wu, M.L. / Hsieh, W.L. / Hsu, K.C. / Hsu, H.L. / Ko, T.P. / Wang, A.H. |
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リンク | J. Mol. Biol. / PubMed:33774034 |
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手法 | X線回折 |
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解像度 | 1.24 - 2.998 Å |
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構造データ | PDB-7d17: Crystal structure of Macrostomum lignano glutaminyl cyclase 手法: X-RAY DIFFRACTION / 解像度: 2.998 Å PDB-7d18: Crystal structure of Acidobacteriales bacterium glutaminyl cyclase 手法: X-RAY DIFFRACTION / 解像度: 1.332 Å PDB-7d1b: Crystal structure of Fimbriiglobus ruber glutaminyl cyclase 手法: X-RAY DIFFRACTION / 解像度: 1.24 Å PDB-7d1d: Crystal structure of Bacteroides thetaiotaomicron glutaminyl cyclase bound to 1-benzylimidazole 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7d1e: Crystal structure of Bacteroides thetaiotaomicron glutaminyl cyclase bound to N-acetylhistamine 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-7d1h: Crystal structure of Ixodes scapularis glutaminyl cyclase with D238A mutation 手法: X-RAY DIFFRACTION / 解像度: 1.69 Å PDB-7d1n: Crystal structure of Ixodes scapularis glutaminyl cyclase with three Cu ions bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-7d1p: Crystal structure of Ixodes scapularis glutaminyl cyclase with three Cd ions bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-7d1y: Crystal structure of Ixodes scapularis glutaminyl cyclase with two Co ions bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7d21: Crystal structure of Ixodes scapularis glutaminyl cyclase with two Zn ions bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-7d23: Crystal structure of Ixodes scapularis glutaminyl cyclase with one K ion bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7d2b: Crystal structure of Ixodes scapularis glutaminyl cyclase with a Ni ion bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å PDB-7d2d: Crystal structure of Ixodes scapularis glutaminyl cyclase with a Mn ion bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7d2i: Crystal structure of Ixodes scapularis glutaminyl cyclase with a Fe ion bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-7d2j: Crystal structure of Ixodes scapularis glutaminyl cyclase with a Cd ion bound to the active site 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
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化合物 | ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
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由来 | macrostomum lignano (無脊椎動物) acidobacteriales bacterium 59-55 (バクテリア) fimbriiglobus ruber (バクテリア) bacteroides thetaiotaomicron (バクテリア) bacteroides thetaiotaomicron cag:40 (バクテリア) ixodes scapularis (ダニ)
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キーワード | TRANSFERASE / Glutaminyl cyclase / METAL BINDING PROTEIN |
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