| タイトル | Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. |
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| ジャーナル・号・ページ | Nat Commun, Vol. 12, Page 3759-3759, Year 2021 |
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| 掲載日 | 2020年8月4日 (構造データの登録日) |
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著者 | Guo, M. / Wang, Y. / Tang, Y. / Chen, Z. / Hou, J. / Dai, J. / Wang, L. / Xu, H. / Tian, B. / Hua, Y. / Zhao, Y. |
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リンク | Nat Commun / PubMed:34145298 |
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| 手法 | X線回折 |
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| 解像度 | 1.599 - 1.9 Å |
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| 構造データ | PDB-7co6: Binary complex of DNA polymerase Mu with 1-nt gapped DNA (templating thymine) 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7co8: Ternary complex of DNA polymerase Mu with 2-nt gapped DNA (T:dGMPNPP) 手法: X-RAY DIFFRACTION / 解像度: 1.697 Å PDB-7co9: Ternary complex of DNA polymerase Mu with 1-nt gapped DNA (T:dGMPNPP) and Mg 手法: X-RAY DIFFRACTION / 解像度: 1.599 Å PDB-7coa: Ternary complex of DNA polymerase Mu with 1-nt gapped DNA (T:dGMPNPP) and Mn 手法: X-RAY DIFFRACTION / 解像度: 1.698 Å PDB-7cob: Ternary complex of DNA polymerase Mu (Q441A) with 1-nt gapped DNA (T:dGMPNPP) 手法: X-RAY DIFFRACTION / 解像度: 1.797 Å PDB-7coc: Ternary complex of DNA polymerase Mu (K438A/Q441A) with 1-nt gapped DNA (T:dGMPNPP) 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-7cod: Post insertion complex of DNA polymerase Mu (K438A/Q441A) with 1-nt gapped DNA 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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| 化合物 | ChemComp-XG4: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine
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| 由来 | homo sapiens (ヒト)- synthetic construct (人工物)
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キーワード | HYDROLASE/DNA / polymerase mu / misincorporation / gap filling / mutagenesis / HYDROLASE / HYDROLASE-DNA complex |
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