EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
ジャーナル・号・ページ	Acs Med. Chem. Lett., Vol. 12, Page 162-167, Year 2021
掲載日	2020年12月1日 (構造データの登録日)
著者	Collie, G.W. / Michaelides, I.N. / Embrey, K. / Stubbs, C.J. / Borjesson, U. / Dale, I.L. / Snijder, A. / Barlind, L. / Song, K. / Khurana, P. ...Collie, G.W. / Michaelides, I.N. / Embrey, K. / Stubbs, C.J. / Borjesson, U. / Dale, I.L. / Snijder, A. / Barlind, L. / Song, K. / Khurana, P. / Phillips, C. / Storer, R.I.
リンク	Acs Med. Chem. Lett. / PubMed:33488978
手法	X線回折
解像度	1.75 - 2.23 Å
構造データ	PDB-7b3q: Crystal structure of c-MET bound by compound 1 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7b3t: Crystal structure of c-MET bound by compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-7b3v: Crystal structure of c-MET bound by compound 3 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-7b3w: Crystal structure of c-MET bound by compound 4 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-7b3z: Crystal structure of c-MET bound by compound 5 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7b40: Crystal structure of c-MET bound by compound 6 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å PDB-7b41: Crystal structure of c-MET bound by compound 7 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-7b42: Crystal structure of c-MET bound by compound 8 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7b43: Crystal structure of c-MET bound by compound 9 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-7b44: Crystal structure of c-MET bound by compound S1 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å
化合物	ChemComp-SV5: 1-(phenylmethyl)-5~{H}-pyrrolo[3,2-c]pyridin-4-one / 1-ベンジル-1H-ピロロ[3,2-c]ピリジン-4(5H)-オン ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-HOH: WATER ChemComp-SVK: 3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridine ChemComp-CL: Unknown entry / クロリド ChemComp-SWB: 3-(3-methyl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)-1~{H}-pyrrolo[3,4-b]pyrrol-6-one ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-SVH: 3-(6-fluoranyl-1~{H}-indazol-4-yl)-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-SV8: 3-[3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one ChemComp-SWN: 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine ChemComp-SWK: 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine ChemComp-SW8: 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine ChemComp-SW5: 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine ChemComp-SVT*: 5-methoxy-1~{H}-indazole / 5-メトキシ-1H-インダゾ-ル
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / c-met / kinase / folded P-loop / inhibitor