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Open data
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Basic information
Entry | Database: PDB / ID: 7b43 | ||||||
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Title | Crystal structure of c-MET bound by compound 9 | ||||||
![]() | Hepatocyte growth factor receptor![]() | ||||||
![]() | ![]() ![]() ![]() ![]() | ||||||
Function / homology | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Collie, G.W. | ||||||
![]() | ![]() Title: Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Authors: Collie, G.W. / Michaelides, I.N. / Embrey, K. / Stubbs, C.J. / Borjesson, U. / Dale, I.L. / Snijder, A. / Barlind, L. / Song, K. / Khurana, P. / Phillips, C. / Storer, R.I. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 120.8 KB | Display | ![]() |
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PDB format | ![]() | 97 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 722.8 KB | Display | ![]() |
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Full document | ![]() | 724.5 KB | Display | |
Data in XML | ![]() | 20.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7b3qC ![]() 7b3tC ![]() 7b3vC ![]() 7b3wC ![]() 7b3zC ![]() 7b40C ![]() 7b41C ![]() 7b42C ![]() 7b44C C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 33786.207 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: P08581, ![]() #2: Chemical | #3: Water | ChemComp-HOH / | ![]() Has ligand of interest | Y | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.61 Å3/Da / Density % sol: 52.91 % |
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Crystal grow![]() | Temperature: 293 K / Method: vapor diffusion, sitting drop / Details: 28 % PEGMME2000, 0.1 M bis-tris pH 6.5 |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS 2M / Detector: PIXEL / Date: Sep 17, 2020 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.87→73.706 Å / Num. obs: 28964 / % possible obs: 70 % / Redundancy: 2.7 % / Biso Wilson estimate: 24.8 Å2 / CC1/2: 0.985 / Rmerge(I) obs: 0.109 / Rpim(I) all: 0.08 / Rrim(I) all: 0.136 / Net I/σ(I): 3.8 |
Reflection shell | Resolution: 1.873→2.023 Å / Redundancy: 2.5 % / Rmerge(I) obs: 0.512 / Num. unique obs: 1449 / CC1/2: 0.741 / Rpim(I) all: 0.382 / Rrim(I) all: 0.642 / % possible all: 34.6 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: internal Resolution: 1.87→18.41 Å / Cor.coef. Fo:Fc: 0.921 / Cor.coef. Fo:Fc free: 0.871 / SU R Cruickshank DPI: 0.298 / Cross valid method: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 0.278 / SU Rfree Blow DPI: 0.219 / SU Rfree Cruickshank DPI: 0.227
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Displacement parameters | Biso max: 97.47 Å2 / Biso mean: 27.59 Å2 / Biso min: 3 Å2
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Refine analyze | Luzzati coordinate error obs: 0.31 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: final / Resolution: 1.87→18.41 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 1.87→1.96 Å / Rfactor Rfree error: 0 / Total num. of bins used: 50
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