タイトル | Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface. |
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ジャーナル・号・ページ | Acs Chem. Biol., Vol. 16, Page 1090-1098, Year 2021 |
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掲載日 | 2013年2月20日 (構造データの登録日) |
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著者 | Nguyen, D. / Xie, X. / Jakobi, S. / Terwesten, F. / Metz, A. / Nguyen, T.X.P. / Palchykov, V.A. / Heine, A. / Reuter, K. / Klebe, G. |
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リンク | Acs Chem. Biol. / PubMed:34081441 |
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手法 | X線回折 |
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解像度 | 1.59 - 2.92 Å |
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構造データ | PDB-4jbr: tRNA-guanine transglycosylase Y330C mutant as covalently linked dimer in space group P6(5)22 手法: X-RAY DIFFRACTION / 解像度: 2.92 Å PDB-7a0b: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with rac-trans-3,4-dihydroxysulfolane 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-7a3v: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with 3-hydroxysulfolane 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7a3x: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with sulfolane 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-7a4k: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with tetramethylene sulfoxide 手法: X-RAY DIFFRACTION / 解像度: 1.68 Å PDB-7a4x: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with dimethyl sulfoxide 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-7a6d: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with rac-trans-4,4-difluorocyclopentane-1,2-diol 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-7a9e: tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with ethyl methyl sulfone 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å PDB-7adn: apo tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å |
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化合物 | ChemComp-RGN: (1~{R},2~{R})-4,4-bis(fluoranyl)cyclopentane-1,2-diol
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由来 | - zymomonas mobilis subsp. mobilis (バクテリア)
- zymomonas mobilis subsp. mobilis (strain atcc 31821 / zm4 / cp4) (バクテリア)
- zymomonas mobilis subsp. mobilis zm4 = atcc 31821 (バクテリア)
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キーワード | TRANSFERASE / covalent dimer / TIM-barrel / guanine / preQ1 / tRNA / enzyme / disulfide / fragment |
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