タイトル | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. |
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ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Vol. 27, Page 802-813, Year 2020 |
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掲載日 | 2020年2月28日 (構造データの登録日) |
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著者 | Mahalingan, K.K. / Keith Keenan, E. / Strickland, M. / Li, Y. / Liu, Y. / Ball, H.L. / Tanner, M.E. / Tjandra, N. / Roll-Mecak, A. |
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リンク | Nat. Struct. Mol. Biol. / PubMed:32747782 |
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手法 | X線回折 |
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解像度 | 1.98 - 3.08 Å |
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構造データ | PDB-6vzq: Engineered TTLL6 mutant bound to alpha-elongation analog 手法: X-RAY DIFFRACTION / 解像度: 3.08 Å PDB-6vzr: Engineered TTLL6 bound to the initiation analog 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6vzs: Engineered TTLL6 mutant bound to gamma-elongation analog 手法: X-RAY DIFFRACTION / 解像度: 2.66 Å PDB-6vzt: TTLL6 bound to ATP 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-6vzu: TTLL6 bound to alpha-elongation analog 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-6vzv: TTLL6 bound to gamma-elongation analog 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-6vzw: TTLL6 bound to the initiation analog 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-RZY: (2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid
ChemComp-RZP: (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid
ChemComp-2TI: (2~{S})-2-[[[(3~{R})-3-acetamido-4-(ethylamino)-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid
ChemComp-S3A: (2~{S})-2-[[[(3~{R})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid
ChemComp-RZV: (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid
ChemComp-S37: (2~{S})-2-[[[(3~{S})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid
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由来 | - mus musculus (ハツカネズミ)
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キーワード | LIGASE / Protein engineering / TTLL6 / amino acid ligase / glutamylation / phosphinic acid based inhibitor / amino-acid ligase / glutamylase / tubulin modification / phosphinic acid inhibitors / initiation / phosphinic acid |
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