タイトル | BAK core dimers bind lipids and can be bridged by them. |
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ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Vol. 27, Page 1024-1031, Year 2020 |
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掲載日 | 2019年11月7日 (構造データの登録日) |
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著者 | Cowan, A.D. / Smith, N.A. / Sandow, J.J. / Kapp, E.A. / Rustam, Y.H. / Murphy, J.M. / Brouwer, J.M. / Bernardini, J.P. / Roy, M.J. / Wardak, A.Z. ...Cowan, A.D. / Smith, N.A. / Sandow, J.J. / Kapp, E.A. / Rustam, Y.H. / Murphy, J.M. / Brouwer, J.M. / Bernardini, J.P. / Roy, M.J. / Wardak, A.Z. / Tan, I.K. / Webb, A.I. / Gulbis, J.M. / Smith, B.J. / Reid, G.E. / Dewson, G. / Colman, P.M. / Czabotar, P.E. |
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リンク | Nat. Struct. Mol. Biol. / PubMed:32929280 |
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手法 | X線回折 |
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解像度 | 1.696 - 2.492 Å |
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構造データ | PDB-6uxm: Crystal structure of BAK core domain BH3-groove-dimer in complex with E. coli lipid 手法: X-RAY DIFFRACTION / 解像度: 2.49 Å PDB-6uxn: Crystal structure of BAK core domain BH3-groove-dimer in complex with phosphatidylserine 手法: X-RAY DIFFRACTION / 解像度: 2.49 Å PDB-6uxo: Crystal structure of BAK core domain BH3-groove-dimer in complex with DDM 手法: X-RAY DIFFRACTION / 解像度: 1.799 Å PDB-6uxp: Crystal structure of BAK core domain BH3-groove-dimer in complex with phosphatidylglycerol 手法: X-RAY DIFFRACTION / 解像度: 2.492 Å PDB-6uxq: Crystal structure of BAK core domain BH3-groove-dimer in complex with POPC and C8E4 手法: X-RAY DIFFRACTION / 解像度: 1.696 Å PDB-6uxr: Crystal structure of BAK core domain BH3-groove-dimer in complex with LysoPC 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-PEE: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE, リン脂質*YM
ChemComp-8SP: O-[(R)-{[(2R)-2,3-bis(octanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
ChemComp-PG8: 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)
ChemComp-LBN: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine / リン脂質*YM
ChemComp-K6G: [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate
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由来 | homo sapiens (ヒト)
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キーワード | APOPTOSIS / Pore-forming Protein |
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