タイトル | Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins |
---|
ジャーナル・号・ページ | Cell Rep, Vol. 30, Page 2526-, Year 2020 |
---|
掲載日 | 2019年9月15日 (構造データの登録日) |
---|
著者 | Lam, K. / Tremblay, J.M. / Vazquez-Cintron, E. / Perry, K. / Ondeck, C. / Webb, R. / McNutt, P.M. / Shoemaker, C.B. / Jin, R. |
---|
リンク | Cell Rep / PubMedで検索 |
---|
手法 | X線回折 |
---|
解像度 | 2.02000221988 - 3.18424332787 Å |
---|
構造データ | PDB-6uc6: Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-H11 手法: X-RAY DIFFRACTION / 解像度: 2.32005878384 Å PDB-6uft: Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12 手法: X-RAY DIFFRACTION / 解像度: 2.90008139771 Å PDB-6uht: Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10 手法: X-RAY DIFFRACTION / 解像度: 2.20001465977 Å PDB-6ui1: Crystal structure of BoNT/A-LCHn domain in complex with VHH ciA-D12, ciA-B5, and ciA-H7 手法: X-RAY DIFFRACTION / 解像度: 2.20000858936 Å PDB-6ul4: Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11 手法: X-RAY DIFFRACTION / 解像度: 3.18424332787 Å PDB-6ul6: Crystal Structure of BoNT/A-LCHn domain in complex with VNA ciA-D12/11/ciA-B5 and VHH ciA-H7 手法: X-RAY DIFFRACTION / 解像度: 2.02000221988 Å |
---|
化合物 | |
---|
由来 | - clostridium botulinum (ボツリヌス菌)
- vicugna pacos (アルパカ)
|
---|
キーワード | HYDROLASE/ANTITOXIN / Botulinum neurotoxin (BoNT) / VHH / receptor-binding domain / TOXIN / ANTITOXIN / HYDROLASE-ANTITOXIN complex / TOXIN/ANTITOXIN / TOXIN-ANTITOXIN complex |
---|