タイトル | Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase. |
---|
ジャーナル・号・ページ | Antimicrob. Agents Chemother., Vol. 64, Year 2020 |
---|
掲載日 | 2019年3月28日 (構造データの登録日) |
---|
著者 | Softley, C.A. / Zak, K.M. / Bostock, M.J. / Fino, R. / Zhou, R.X. / Kolonko, M. / Mejdi-Nitiu, R. / Meyer, H. / Sattler, M. / Popowicz, G.M. |
---|
リンク | Antimicrob. Agents Chemother. / PubMed:32205343 |
---|
手法 | X線回折 |
---|
解像度 | 1.9 - 2.85 Å |
---|
構造データ | PDB-6r73: Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed meropenem 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6r78: Structure of IMP-13 metallo-beta-lactamase in apo form (loop closed) 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å PDB-6r79: Structure of IMP-13 metallo-beta-lactamase in apo form (loop open) 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6rzr: Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed imipenem 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6rzs: Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed ertapenem 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6s0h: Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed doripenem 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å |
---|
化合物 | ChemComp-LMP: (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy
ChemComp-KQ8: (2~{R},3~{R})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-3-methyl-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-2,3-dihydro-1~{H}-pyrrole-5-carboxylic acid
|
---|
由来 | ![](img/tx_bacteria.gif) pseudomonas aeruginosa (緑膿菌) klebsiella pneumoniae (肺炎桿菌)
|
---|
キーワード | HYDROLASE / Metallo-Beta-Lactamase / Zinc-binding protein / antibiotic resistance / metallo-beta-lactamase beta-lactamase |
---|