タイトル | Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. |
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ジャーナル・号・ページ | Protein Sci., Vol. 28, Page 1850-1864, Year 2019 |
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掲載日 | 2019年6月11日 (構造データの登録日) |
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著者 | Lubkowski, J. / Wlodawer, A. |
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リンク | Protein Sci. / PubMed:31423681 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.12 Å |
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構造データ | PDB-6pa2: E. coli L-asparaginase II mutant (K162M) in complex with L-Asp at pH 5.6 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6pa3: E. coli L-asparaginase II double mutant (T89V,K162T) in complex with L-Asn at pH 7.0 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-6pa4: E. coli L-asparaginase II double mutant (T89V,K162T) in complex with L-Asp at pH 7.0 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6pa5: ECAII(T89V,K162T) MUTANT IN COMPLEX WITH L-ASN AT PH 8.3 IN SPACE GROUP P2(1) 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6pa6: ECAII(T89V,K162T) MUTANT IN COMPLEX WITH L-ASN AT PH 8.3 in space group C2 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-6pa8: ECAII(T89V,K162T) MUTANT IN COMPLEX WITH L-ASN AT PH 7.0 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6pa9: E. coli L-asparaginase II mutant (T12V) in complex with L-Asn at pH 7.0 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6paa: E. coli L-asparaginase II mutant (T12V) in complex with L-Asp at pH 5.5 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6pab: E. coli L-asparaginase II in complex with L-Asp at pH 7.0 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-6pac: E. coli L-asparaginase II in complex with L-Asp at pH 5.6 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6pae: Dickeya chrysanthemi complex with L-Asp at pH 5.6 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
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化合物 | |
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由来 | ![](img/tx_bacteria.gif) escherichia coli (strain k12) (大腸菌) dickeya chrysanthemi (バクテリア)
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キーワード | HYDROLASE / inactive mutant / hydrolysis of L-asparagine |
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