EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
ジャーナル・号・ページ	ACS Med Chem Lett, Vol. 9, Page 490-495, Year 2018
掲載日	2018年2月26日 (構造データの登録日)
著者	Vulpetti, A. / Ostermann, N. / Randl, S. / Yoon, T. / Mac Sweeney, A. / Cumin, F. / Lorthiois, E. / Rudisser, S. / Erbel, P. / Maibaum, J.
リンク	ACS Med Chem Lett / PubMed:29795765
手法	X線回折
解像度	1.37 - 2.25 Å
構造データ	PDB-6fty: COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å PDB-6ftz: COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 6 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å PDB-6fug: Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å PDB-6fuh: Complement factor D in complex with the inhibitor (4-((3-(aminomethyl)phenyl)amino)quinazolin-2-yl)-L-valine 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-6fui: Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol 手法: X-RAY DIFFRACTION / 解像度: 1.38 Å PDB-6fuj: Complement factor D in complex with the inhibitor N-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)-3-methylbutanamide 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-6fut: Complement factor D in complex with the inhibitor (S)-3'-(aminomethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-[1,1'-biphenyl]-3-carboxamide 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å
化合物	ChemComp-E7H: 4-[[(5~{S},7~{R})-3-azanyl-1-adamantyl]carbonylamino]-1~{H}-indole-2-carboxamide ChemComp-GOL: GLYCEROL ChemComp-HOH: WATER ChemComp-E7E: ~{N}4-[3-(aminomethyl)phenyl]-1~{H}-indole-2,4-dicarboxamide ChemComp-E85: 3-[[3-[[3-(aminomethyl)phenyl]amino]-1~{H}-pyrazolo[3,4-d]pyrimidin-4-yl]amino]phenol ChemComp-E88: (2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]-3-methyl-butanoic acid ChemComp-E7W: (1~{R},2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]cyclohexane-1-carboxylic acid ChemComp-E8B: ~{N}-[3-[3-(aminomethyl)phenyl]phenyl]-3-methyl-butanamide ChemComp-E82: 3-[3-(aminomethyl)phenyl]-~{N}-[(1~{S})-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide ChemComp-SIN: SUCCINIC ACID
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / SERINE PROTEASE / inhibitor / complex / protease / inhibitor complex