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-Structure paper
タイトル | Cryo-EM structure of the polycystin 2-l1 ion channel. |
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ジャーナル・号・ページ | Elife, Vol. 7, Year 2018 |
掲載日 | 2018年7月13日 |
著者 | Raymond E Hulse / Zongli Li / Rick K Huang / Jin Zhang / David E Clapham / |
PubMed 要旨 | We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation- ...We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1. |
リンク | Elife / PubMed:30004384 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.11 Å |
構造データ | |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | MEMBRANE PROTEIN / polycystic 2-l1 / pc2l1 / pkd2l1 / TRPP2 |