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-Structure paper
Title | Cryo-EM structure of the polycystin 2-l1 ion channel. |
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Journal, issue, pages | Elife, Vol. 7, Year 2018 |
Publish date | Jul 13, 2018 |
Authors | Raymond E Hulse / Zongli Li / Rick K Huang / Jin Zhang / David E Clapham / |
PubMed Abstract | We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation- ...We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1. |
External links | Elife / PubMed:30004384 / PubMed Central |
Methods | EM (single particle) |
Resolution | 3.11 Å |
Structure data | |
Chemicals | ChemComp-NAG: |
Source |
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Keywords | MEMBRANE PROTEIN / polycystic 2-l1 / pc2l1 / pkd2l1 / TRPP2 |