タイトル | Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. |
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ジャーナル・号・ページ | Nat Commun, Vol. 10, Page 402-402, Year 2019 |
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掲載日 | 2018年2月26日 (構造データの登録日) |
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著者 | Whitesell, L. / Robbins, N. / Huang, D.S. / McLellan, C.A. / Shekhar-Guturja, T. / LeBlanc, E.V. / Nation, C.S. / Hui, R. / Hutchinson, A. / Collins, C. ...Whitesell, L. / Robbins, N. / Huang, D.S. / McLellan, C.A. / Shekhar-Guturja, T. / LeBlanc, E.V. / Nation, C.S. / Hui, R. / Hutchinson, A. / Collins, C. / Chatterjee, S. / Trilles, R. / Xie, J.L. / Krysan, D.J. / Lindquist, S. / Porco Jr., J.A. / Tatu, U. / Brown, L.E. / Pizarro, J. / Cowen, L.E. |
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リンク | Nat Commun / PubMed:30679438 |
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手法 | X線回折 |
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解像度 | 1.64 - 2.6 Å |
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構造データ | PDB-6cji: Candida albicans Hsp90 nucleotide binding domain 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-6cjj: Candida albicans Hsp90 nucleotide binding domain in complex with ADP 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-6cjl: Candida albicans Hsp90 nucleotide binding domain in complex with radicicol 手法: X-RAY DIFFRACTION / 解像度: 1.6972 Å PDB-6cjp: Candida albicans Hsp90 nucleotide binding domain in complex with radicicol 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6cjr: Candida albicans Hsp90 nucleotide binding domain in complex with SNX-2112 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-6cjs: Candida albicans Hsp90 nucleotide binding domain in complex with AUY922 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
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化合物 | ChemComp-F5S: (1aR,2Z,4E,6E,14R,15aR)-9,11-dihydroxy-6-{[(4-methoxyphenyl)methoxy]imino}-14-methyl-1a,6,7,14,15,15a-hexahydro-12H-oxireno[e][2]benzoxacyclotetradecin-12-one
ChemComp-E0G: 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide / SNX-2112
ChemComp-2GJ: 5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE / NVP-AUY-922
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由来 | candida albicans (strain sc5314 / atcc mya-2876) (酵母)
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キーワード | CHAPERONE / Hsp90. ATPase / Structural Genomics / Structural Genomics Consortium / SGC |
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