EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
ジャーナル・号・ページ	J. Med. Chem., Vol. 61, Page 4517-4527, Year 2018
掲載日	2018年2月11日 (構造データの登録日)
著者	Ferreira de Freitas, R. / Harding, R.J. / Franzoni, I. / Ravichandran, M. / Mann, M.K. / Ouyang, H. / Lautens, M. / Santhakumar, V. / Arrowsmith, C.H. / Schapira, M.
リンク	J. Med. Chem. / PubMed:29741882
手法	X線回折
解像度	1.55 - 1.8 Å
構造データ	PDB-6ce6: Structure of HDAC6 zinc-finger ubiquitin binding domain soaked with 3,3'-(benzo[1,2-d:5,4-d']bis(thiazole)-2,6-diyl)dipropionic acid 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6ce8: Crystal structure of fragment 2-(Benzo[d]thiazol-2-yl)acetic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-6cea: Crystal structure of fragment 3-(quinolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-6cec: Crystal structure of fragment 3-(3-Methoxy-2-quinoxalinyl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-6ced: Crystal structure of fragment 3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6cee: Crystal structure of fragment 3-(1-Methyl-2-oxo-1,2-dihydroquinoxalin-3-yl)propionic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-6cef: Crystal structure of fragment 3-(1,3-Benzothiazol-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-UNX: Unknown entry ChemComp-EYP: 3,3'-(benzo[1,2-d:5,4-d']bis[1,3]thiazole-2,6-diyl)dipropanoic acid ChemComp-HOH: WATER ChemComp-EYV: (1,3-benzothiazol-2-yl)acetic acid / ベンゾチアゾ-ル-2-酢酸 ChemComp-EYY: 3-(quinolin-2-yl)propanoic acid ChemComp-EY7: 3-(3-methoxyquinoxalin-2-yl)propanoic acid ChemComp-EYA: 3-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid ChemComp-EYM: 3-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acid ChemComp-EYJ: 3-(1,3-benzothiazol-2-yl)propanoic acid / ベンゾチアゾ-ル-2-プロピオン酸
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / HISTONE DEACETYLASE / HDAC / HDAC6 / UBIQUITIN / STRUCTURAL GENOMICS CONSORTIUM / SGC