タイトル | The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. |
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ジャーナル・号・ページ | Protein Sci., Vol. 26, Page 2367-2380, Year 2017 |
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掲載日 | 2017年4月3日 (構造データの登録日) |
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著者 | Hall, J. / Ralph, E.C. / Shanker, S. / Wang, H. / Byrnes, L.J. / Horst, R. / Wong, J. / Brault, A. / Dumlao, D. / Smith, J.F. ...Hall, J. / Ralph, E.C. / Shanker, S. / Wang, H. / Byrnes, L.J. / Horst, R. / Wong, J. / Brault, A. / Dumlao, D. / Smith, J.F. / Dakin, L.A. / Schmitt, D.C. / Trujillo, J. / Vincent, F. / Griffor, M. / Aulabaugh, A.E. |
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リンク | Protein Sci. / PubMed:28940468 |
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手法 | X線回折 |
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解像度 | 2.3 - 3.246 Å |
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構造データ | PDB-5vdo: Human cyclic GMP-AMP synthase (cGAS) in complex with 2',2'-cGAMP 手法: X-RAY DIFFRACTION / 解像度: 3.218 Å PDB-5vdp: Human cyclic GMP-AMP synthase (cGAS) in complex with 2',3'-cGAMP 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5vdq: Human cyclic GMP-AMP synthase (cGAS) in complex with 2',5'-GpAp 手法: X-RAY DIFFRACTION / 解像度: 3.246 Å PDB-5vdr: Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdIMP 手法: X-RAY DIFFRACTION / 解像度: 3.042 Å PDB-5vds: Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdUMP 手法: X-RAY DIFFRACTION / 解像度: 2.766 Å PDB-5vdt: Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cGAMP 手法: X-RAY DIFFRACTION / 解像度: 2.576 Å PDB-5vdu: Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F2 手法: X-RAY DIFFRACTION / 解像度: 2.729 Å PDB-5vdv: Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F3 手法: X-RAY DIFFRACTION / 解像度: 2.998 Å PDB-5vdw: Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F1 手法: X-RAY DIFFRACTION / 解像度: 2.711 Å |
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化合物 | ChemComp-1YC: 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one / 2′-O,5′-O-[(グアノシン-2′-O,5′-O-ジイル)ビスホスフィニコ]アデノシン
ChemComp-4BW: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one / cGAMP
ChemComp-9BY: [2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetic acid
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / STING / cGAMP |
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