タイトル | New Antibiotic Candidates against Helicobacter pylori. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 137, Page 14275-14280, Year 2015 |
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掲載日 | 2014年10月2日 (構造データの登録日) |
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著者 | Wang, S. / Cameron, S.A. / Clinch, K. / Evans, G.B. / Wu, Z. / Schramm, V.L. / Tyler, P.C. |
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リンク | J. Am. Chem. Soc. / PubMed:26494017 |
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手法 | X線回折 |
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解像度 | 1.58 - 2.1 Å |
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構造データ | PDB-4wkn: Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4wko: Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hydroxybutylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4wkp: Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-4ynb: Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with pyrazinylthio-DADMe-Immucillin-A 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4yo8: Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)(hexyl)amino)methanol 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-GMD: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(4-hydroxybutyl)sulfanyl]methyl}pyrrolidin-3-ol
ChemComp-3QA: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(2-{[2-(2-hydroxyethoxy)ethyl]sulfanyl}ethyl)pyrrolidin-3-ol
ChemComp-4EH: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(pyrazin-2-ylsulfanyl)methyl]pyrrolidin-3-ol
ChemComp-4EZ: {[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](hexyl)amino}methanol
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由来 | ![](img/tx_bacteria.gif) helicobacter pylori (ピロリ菌)
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キーワード | hydrolase/hydrolase inhibitor / hydrolase / hydrolase-hydrolase inhibitor complex / Hydrolase/inhibitor / Hydrolase-inhibitor complex |
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