タイトル | Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 53, Page 10728-, Year 2014 |
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掲載日 | 2014年7月21日 (構造データの登録日) |
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著者 | Roessler, C. / Nowak, T. / Pannek, M. / Gertz, M. / Nguyen, G.T. / Scharfe, M. / Born, I. / Sippl, W. / Steegborn, C. / Schutkowski, M. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:25111069 |
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手法 | X線回折 |
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解像度 | 2.4 - 3.3 Å |
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構造データ | PDB-4utn: Crystal structure of zebrafish Sirtuin 5 in complex with succinylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4utr: Crystal structure of zebrafish Sirtuin 5 in complex with glutarylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4utv: Crystal structure of zebrafish Sirtuin 5 in complex with 3-phenyl- succinylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4utx: Crystal structure of zebrafish Sirtuin 5 in complex with 3-nitro- propionylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-4utz: Crystal structure of zebrafish Sirtuin 5 in complex with adipoylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-4uu7: Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4uu8: Crystal structure of zebrafish Sirtuin 5 in complex with 3,3-dimethyl- succinylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4uua: Crystal structure of zebrafish Sirtuin 5 in complex with 3S-Z-amino- succinylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-4uub: Crystal structure of zebrafish Sirtuin 5 in complex with 2R-butyl- succinylated CPS1-peptide 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å |
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化合物 | ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-3NP: 3-NITROPROPANOIC ACID / 阻害剤, アゴニスト, toxin*YM
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由来 | ![](img/tx_fish.gif) danio rerio (ゼブラフィッシュ) homo sapiens (ヒト)
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キーワード | HYDROLASE / REGULATORY ENZYME / ROSSMANN-FOLD / ZINC-BINDING / SIRTUIN 5 / DEACYLASE / MITOCHONDRIAL |
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