タイトル | Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. |
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ジャーナル・号・ページ | Biochemistry, Vol. 53, Page 4671-4684, Year 2014 |
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掲載日 | 2014年4月12日 (構造データの登録日) |
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著者 | Hai, Y. / Edwards, J.E. / Van Zandt, M.C. / Hoffmann, K.F. / Christianson, D.W. |
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リンク | Biochemistry / PubMed:25007099 |
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手法 | X線回折 |
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解像度 | 1.831 - 2.7 Å |
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構造データ | PDB-4q3p: Crystal structure of Schistosoma mansoni arginase 手法: X-RAY DIFFRACTION / 解像度: 2.501 Å PDB-4q3q: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABH 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-4q3r: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHDP 手法: X-RAY DIFFRACTION / 解像度: 2.169 Å PDB-4q3s: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE 手法: X-RAY DIFFRACTION / 解像度: 2.11 Å PDB-4q3t: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor NOHA 手法: X-RAY DIFFRACTION / 解像度: 2.142 Å PDB-4q3u: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor nor-NOHA 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4q3v: Crystal structure of Schistosoma mansoni arginase in complex with inhibitor BEC 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4q40: Crystal structure of Schistosoma mansoni arginase in complex with L-valine 手法: X-RAY DIFFRACTION / 解像度: 1.831 Å PDB-4q41: Crystal structure of Schistosoma mansoni arginase in complex with L-lysine 手法: X-RAY DIFFRACTION / 解像度: 2.199 Å PDB-4q42: Crystal structure of Schistosoma mansoni arginase in complex with L-ornithine 手法: X-RAY DIFFRACTION / 解像度: 2.051 Å |
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化合物 | ChemComp-XA2: (R)-2-amino-6-borono-2-(1-(3,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid
ChemComp-X7A: [(5R)-5-amino-5-carboxy-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-)
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由来 | - schistosoma mansoni (マンソン住血吸虫)
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キーワード | HYDROLASE / arginase-deacetylase fold / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |
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