タイトル | Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 428, Page 3999-4012, Year 2016 |
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掲載日 | 2014年5月9日 (構造データの登録日) |
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著者 | Driggers, C.M. / Kean, K.M. / Hirschberger, L.L. / Cooley, R.B. / Stipanuk, M.H. / Karplus, P.A. |
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リンク | J. Mol. Biol. / PubMed:27477048 |
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手法 | X線回折 |
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解像度 | 1.2469 - 1.6 Å |
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構造データ | PDB-4pix: Unliganded Cysteine Dioxygenase C93A variant at pH 6.2 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-4piy: Homocysteine bound Cysteine Dioxygenase C93A variant at pH 6.2 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-4piz: Homocysteine-bound Cysteine Dioxygenase at pH 6.2 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4pjy: Azide bound Cysteine Dioxygenase at pH 6.2 手法: X-RAY DIFFRACTION / 解像度: 1.501 Å PDB-4xet: Fe-Cl bound Y157F CDO at pH ~7.0 in the presence of azide 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-4xez: cysteine dioxygenase variant - Y157F at pH 8.0 with dithionite 手法: X-RAY DIFFRACTION / 解像度: 1.2469 Å PDB-4xf0: cysteine dioxygenase variant - C93A at pH 8.0 with cysteine 手法: X-RAY DIFFRACTION / 解像度: 1.3994 Å PDB-4xf1: cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4xf3: cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine and dithionite 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4xf4: Cysteine dioxygenase at pH 8.0 in complex with homocysteine 手法: X-RAY DIFFRACTION / 解像度: 1.3485 Å PDB-4xf9: cysteine dioxygenase variant - C93A at pH 8.0 in complex with homocysteine 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-4xfb: cysteine dioxygenase variant - C93A at pH 8.0 unliganded 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-4xfc: cysteine dioxygenase variant - Y157F at pH 6.2 unliganded 手法: X-RAY DIFFRACTION / 解像度: 1.351 Å PDB-4xff: cysteine dioxygenase variant - Y157F at pH 6.2 with dithionite 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-4xfg: cysteine dioxygenase variant - C93A at pH 6.2 with cysteine 手法: X-RAY DIFFRACTION / 解像度: 1.401 Å PDB-4xfh: cysteine dioxygenase variant - Y157F at pH 6.2 with cysteine 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-4xfi: cysteine dioxygenase variant - Y157F at pH 6.2 with homocysteine 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-5i0r: D-cysteine bound C93A mutant of Cysteine Dioxygenase at pH 8 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-5i0s: Thiosulfate bound Cysteine Dioxygenase at pH 6.2 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-5i0t: Thiosulfate bound Cysteine Dioxygenase at pH 6.8 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-5i0u: Incompletely interpreted D-cysteine soak of Cysteine Dioxygenase at pH 7.0 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å |
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化合物 | |
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由来 | - rattus norvegicus (ドブネズミ)
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キーワード | OXIDOREDUCTASE / Cupin Fold / cysteine to cysteine sulfinic acid catalysis / Cytosol / catalyzes oxidation / cysteine to cysteine sulfinate / C93-Y157 crosslink / thiol dioxygenase / cupin-fold / D-cysteine / catalysis oxidation / thiosulfate |
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