タイトル | Cysteine Dioxygenase Structures from pH4 to 9: Consistent Cys-Persulfenate Formation at Intermediate pH and a Cys-Bound Enzyme at Higher pH. |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 425, Page 3121-3136, Year 2013 |
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掲載日 | 2012年12月13日 (構造データの登録日) |
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著者 | Driggers, C.M. / Cooley, R.B. / Sankaran, B. / Hirschberger, L.L. / Stipanuk, M.H. / Karplus, P.A. |
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リンク | J. Mol. Biol. / PubMed:23747973 |
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手法 | X線回折 |
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解像度 | 1.25 - 2.15 Å |
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構造データ | PDB-4ieo: unliganded Cysteine Dioxygenase at pH 4.0 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4iep: unliganded Cysteine Dioxygenase at pH 4.5 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4ieq: unliganded Cysteine Dioxygenase at pH 5.0 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.396 Å PDB-4ier: Cys-persulfenate bound Cysteine Dioxygenase at pH 5.5 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4ies: Cys-persulfenate bound Cysteine Dioxygenase at pH 6.2 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4iet: Cys-persulfenate bound Cysteine Dioxygenase at pH 6.8 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4ieu: Cys-persulfenate bound Cysteine Dioxygenase at pH 7.0 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-4iev: Cys-only bound Cysteine Dioxygenase at pH 8.0 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-4iew: Cys-only bound Cysteine Dioxygenase at pH 9.0 in the presence of Cys 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4iex: unliganded room-temp Cysteine Dioxygenase at pH 6.2 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-4iey: Cys-persulfenate bound Cysteine Dioxygenase at pH 7.0 in the presence of Cys, home-source structure 手法: X-RAY DIFFRACTION / 解像度: 1.63 Å PDB-4iez: unliganded Cysteine Dioxygenase at pH 8.0 手法: X-RAY DIFFRACTION / 解像度: 1.39 Å PDB-4jtn: Cysteine Dioxygenase at pH 8.0 in the presence of dithionite 手法: X-RAY DIFFRACTION / 解像度: 1.593 Å PDB-4jto: Cysteine bound Cysteine Dioxygenase at pH 8.0 in the presence of Cys and dithionite 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | |
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由来 | ![](img/tx_mammal.gif) rattus norvegicus (ドブネズミ)
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キーワード | OXIDOREDUCTASE / Cupin fold / catalyzes oxidation / cysteine to cysteine sulfinate / C93-Y157 crosslink / Cytosol / cysteine to cysteine sulfinic acid catalysis |
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