EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo.
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 109, Page 17448-17453, Year 2012
掲載日	2012年3月9日 (構造データの登録日)
著者	Eidam, O. / Romagnoli, C. / Dalmasso, G. / Barelier, S. / Caselli, E. / Bonnet, R. / Shoichet, B.K. / Prati, F.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:23043117
手法	X線回折
解像度	1.4299 - 1.7999 Å
構造データ	PDB-4e3i: Crystal structure of AmpC beta-lactamase in complex with a designed 3-carboxyl benzyl sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-4e3j: Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl benzene sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.7999 Å PDB-4e3k: Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl pyridine sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.4299 Å PDB-4e3l: Crystal structure of AmpC beta-lactamase in complex with a 3-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-4e3m: Crystal structure of AmpC beta-lactamase in complex with a 2-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.44 Å PDB-4e3n: Crystal structure of AmpC beta-lactamase in complex with a 2-trifluoromethyl-4-tetrazolyl benzene sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.49 Å PDB-4e3o: Crystal structure of AmpC beta-lactamase in complex with a small chloromethyl sulfonamide boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å
化合物	ChemComp-0N3: 3-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-HOH: WATER ChemComp-0N4: [({[4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid ChemComp-0NA: [({[6-(1H-tetrazol-5-yl)pyridin-3-yl]sulfonyl}amino)methyl]boronic acid ChemComp-0NB: [({[3-chloro-4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid ChemComp-0ND: [({[2-chloro-4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid ChemComp-0NE: [({[4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]boronic acid ChemComp-0NG: ({[(chloromethyl)sulfonyl]amino}methyl)boronic acid
由来	escherichia coli (大腸菌)
キーワード	HYDROLASE/HYDROLASE INHIBITOR / AMPC beta-lactamase / class c / hydrolase / cephalosporinase / HYDROLASE-HYDROLASE INHIBITOR complex