タイトル | Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. |
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ジャーナル・号・ページ | Plos One, Vol. 8, Page 65689-, Year 2013 |
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掲載日 | 2012年10月5日 (構造データの登録日) |
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著者 | Silva-Santisteban, M.C. / Westwood, I.M. / Boxall, K. / Brown, N. / Peacock, S. / Mcandrew, C. / Barrie, E. / Richards, M. / Mirza, A. / Oliver, A.W. ...Silva-Santisteban, M.C. / Westwood, I.M. / Boxall, K. / Brown, N. / Peacock, S. / Mcandrew, C. / Barrie, E. / Richards, M. / Mirza, A. / Oliver, A.W. / Burke, R. / Hoelder, S. / Jones, K. / Aherne, G.W. / Blagg, J. / Collins, I. / Garrett, M.D. / Van Montfort, R.L. |
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リンク | Plos One / PubMed:23776527 |
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手法 | X線回折 |
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解像度 | 2.32 - 3.3 Å |
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構造データ | PDB-4bda: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-4bdb: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4bdc: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4bdd: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.67 Å PDB-4bde: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-4bdf: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4bdg: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.84 Å PDB-4bdh: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4bdi: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 2.32 Å PDB-4bdj: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 3.01 Å PDB-4bdk: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å |
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化合物 | ChemComp-VFB: 3,4-dihydro[1,2,4]triazolo[1,5-a][3,1]benzimidazol-9-ium
ChemComp-ODH: N-(furan-2-ylmethyl)quinoxaline-6-carboxamide
ChemComp-WVI: 3-METHYL-4-(THIOPHEN-2-YL)-1H-PYRAZOL-5-AMINE
ChemComp-HAU: 1-acetyl-N-(5-methylpyridin-2-yl)piperidine-4-carboxamide
ChemComp-Z2M: 3-cyclopropyl-4-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridine
ChemComp-RQQ: N-[(4-methoxyphenyl)methyl]quinoxaline-6-carboxamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / INHIBITOR |
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