EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
ジャーナル・号・ページ	Plos Pathog., Vol. 8, Page e1002832-e1002832, Year 2012
掲載日	2011年7月11日 (構造データの登録日)
著者	Romano, K.P. / Ali, A. / Aydin, C. / Soumana, D. / Ozen, A. / Deveau, L.M. / Silver, C. / Cao, H. / Newton, A. / Petropoulos, C.J. ...Romano, K.P. / Ali, A. / Aydin, C. / Soumana, D. / Ozen, A. / Deveau, L.M. / Silver, C. / Cao, H. / Newton, A. / Petropoulos, C.J. / Huang, W. / Schiffer, C.A.
リンク	Plos Pathog. / PubMed:22910833
手法	X線回折
解像度	1.1 - 2.5 Å
構造データ	PDB-3su0: Crystal structure of NS3/4A protease variant R155K in complex with danoprevir 手法: X-RAY DIFFRACTION / 解像度: 1.159 Å PDB-3su1: Crystal structure of NS3/4A protease variant D168A in complex with danoprevir 手法: X-RAY DIFFRACTION / 解像度: 1.399 Å PDB-3su2: Crystal structure of NS3/4A protease variant A156T in complex with danoprevir 手法: X-RAY DIFFRACTION / 解像度: 1.496 Å PDB-3su3: Crystal structure of NS3/4A protease in complex with vaniprevir 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-3su4: Crystal structure of NS3/4A protease variant R155K in complex with vaniprevir 手法: X-RAY DIFFRACTION / 解像度: 2.255 Å PDB-3su5: Crystal structure of NS3/4A protease variant D168A in complex with vaniprevir 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-3su6: Crystal structure of NS3/4A protease variant A156T in complex with vaniprevir 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-3sud: Crystal structure of NS3/4A protease in complex with MK-5172 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-3sue: Crystal structure of NS3/4A protease variant R155K in complex with MK-5172 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3suf: Crystal structure of NS3/4A protease variant D168A in complex with MK-5172 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-3sug: Crystal structure of NS3/4A protease variant A156T in complex with MK-5172 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3sv6: Crystal structure of NS3/4A protease in complex with Telaprevir 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-3sv7: Crystal structure of NS3/4A protease variant R155K in complex with Telaprevir 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-3sv8: Crystal structure of NS3/4A protease variant D168A in complex with Telaprevir 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3sv9: Crystal structure of NS3/4A protease variant A156T in complex with Telaprevir 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å
化合物	ChemComp-TSV: (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 / 阻害剤YM ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-ZN: Unknown entry ChemComp-HOH: WATER ChemComp-SU3: (5R,7S,10S)-10-tert-butyl-N-{(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethylcyclopropyl}-15,15-dimethyl-3,9,12-trioxo-6,7,9,10,11,12,14,15,16,17,18,19-dodecahydro-1H,5H-2,23:5,8-dimethano-4,13,2,8,11-benzodioxatriazacyclohenicosine-7(3H)-carboxamide / プロテアーゼ阻害剤YM ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-SUE: (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-di / グラゾプレビル / プロテアーゼ阻害剤YM ChemComp-SV6: (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide / 抗ウイルス剤, プロテアーゼ阻害剤YM
由来	hepatitis c virus subtype 1a (C型肝炎ウイルス) hepatitis c virus (ウイルス)
キーワード	HYDROLASE/HYDROLASE INHIBITOR / NS3 / drug resistance / drug design / Protease inhibitors / HCV / serine protease / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE/INHIBITOR / VIRAL PROTEIN / HYDROLASE-INHIBITOR complex