EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 108, Page 20982-20987, Year 2011
掲載日	2009年1月10日 (構造データの登録日)
著者	Torbeev, V.Y. / Raghuraman, H. / Hamelberg, D. / Tonelli, M. / Westler, W.M. / Perozo, E. / Kent, S.B.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:22158985
手法	X線回折
解像度	1.3 - 1.9 Å
構造データ	PDB-3fsm: CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-Ala51,D-Ala51'] HIV-1 PROTEASE MOLECULE 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3hau: Crystal structure of chemically synthesized HIV-1 protease with reduced isostere MVT-101 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-3haw: Crystal structure of [L-Ala51/51']HIV-1 protease with reduced isostere MVT-101 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-3hbo: Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-3hdk: Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3hlo: Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3iaw: Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-3ka2: Crystal structure of chemically synthesized 203 amino acid 'covalent dimer' [L-Ala;Gly51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.4 A resolution 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-3nwq: X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-3nwx: X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3nxe: X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with MVT-101 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-3nxn: X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3nyg: X-ray structure of ester chemical analogue [O-Gly51,O-Gly51']HIV-1 protease complexed with MVT-101 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å
化合物	ChemComp-2NC: N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide ChemComp-HOH: WATER ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-KVS: N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide
キーワード	HYDROLASE/HYDROLASE INHIBITOR / asymmetric dimer / covalent dimer / beta-sheet / HYDROLASE-HYDROLASE INHIBITOR complex / beta barrel / HYDROLASE / beta-barrel